Synthesis and biological evaluation of chalcone derivatives of oxazole-pyrimidines as anticancer agents

Synthesis and biological evaluation of chalcone derivatives of oxazole-pyrimidines as anticancer agents

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We have developed a new library of chalcone derivatives of oxazole-pyrimidines (16a-j) and their structures were confirmed by analytical data.Further, in vitro anticancer activity Hockey Accessories - Bags - Carry of the newly prepared compounds 16a-j was assessed against a panel of four human cancer cell lines such as human breast cancer (MCF-7), human lung cancer (A549), human colon cancer (Colo-205) and human ovarian cancer FIBRESMART (A2780) by using of MTT method.All the screened compounds displayed remarkable anticancer activity as compared with etoposide used as positive control.Among them, five compounds 16a, 16 g, 16 h, 16i &16j possessed more potent activity.Particularly, one compound 16j with 3,5-dinitro group showed superior activity.